Urine Drug Screen, Comprehensive by LCMSMS

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URINE DRUG SCREEN, COMPREHENSIVE BY LCMSMS

Comprehensive testing for prescription and illicit drugs and associated metabolites to include:
Barbiturates (Amobarbital, Butalbital, Pentobarbital, Phenobarbital, Secobarbital); Benzodiazepines (Alprazolam, Clonazepam, Diazepam, Flurazepam, Lorazepam, Midazolam, Oxazepam, Temazepam, Triazolam) ; Opiates/ Opioid Antagonists (Tapentodol,  Codeine,  Fentanyl, Hydrocodone, Hydromorphone, Meperidine, Methadone, Morphine, Oxycodone, Oxymorphone, Naloxone, Naltrexone) ; Stimulants (Amphetamines, Methamphetamine, Methylphenidate, Phentermine, Pseudoephedrine); Cannabinoids (THC-COOH-Marijuana metabolite); Cocaine Metabolite (Benzoylecgonine); Other Analytes and Metabolites such as Buprenorphine, Carisoprodol, 6-MAM (Heroine), Diphenhydramine , Ketamine, LSD , Naltrexone, Naloxone, Norbuprenorphine , MDEA (Ecstacy-Like), MDA (Ecstasy-Like), MDMA (Ecstasy), Meprobamate, and Phenylcyclidine (PCP).
A complete list of Drugs / Metabolites and their respective synonyms and prescription names can be found on the Analyte Medication List.
 
TURNAROUND TIME:   2 - 3 days
 
PERFORMED :  Monday through Friday  
 
TESTING METHODOLOGY:
High Performance Liquid Chromatography Triple Quadrupole Mass Spectrometer (LC/MSMS).
 
SPECIMEN REQUIREMENTS:
A Biochemical Genetics Test Requisition form should be submitted with the specimen if not ordered directly in hospital information system.
  • Collect: 20 mLs random urine collected in sterile cup.  Transfer 10 mL to two vaccuette urine containers with no additives or preservatives.
  • Min. Collection: Two vaccuette urine containers with 2.0 mL each.
  • Transport:  Room Temperature; Store refrigerated if analysis is not performed immediately.
  • Stability: Ambient:  5 days; Refrigerated: 2 weeks; Frozen: 2 months.
  • Unacceptable Conditions:  Specimen exposed to repeated freeze/thaw cycles or transferred into a tube or cup containing additives or preservatives.
REFERENCE INTERVAL:
Postive or Negative
 
INTERPRETATIVE DATA:
Negative findings may be the result of timing of specimen collection relative to drug exposure, interindividual variations in pharmacokinetics, testing limitations, and or diluted or adulterated urine.
Drug metabolism or exposure to multiple drugs can lead to detection of multiple analytes in urine.  Pharmaceutical manufacturing impurities can result in low concentrations of an anticipated analyte in the presence of large concentrations of another related analyte.
Specimens for which drugs or drug metabolites are detected by the screen can be reflexed upon request to a second specific confirmatory quantitative procedure by LCMSMS (Liquid Chromatography Tandem Mass Spectrometry).  Additional charges will apply.
Interpretive questions should be directed to the laboratory.
 
ANALYTIC SENSITIVITY: >99%
 
TEST LIMITATIONS:
Urine creatinine results less than 20mg/dL may indicate adulterated/diluted urine.  Recollection of urine specimen may be requested and preferably from, early morning clean catch collection.
Methamphetamine exists in the d- and l- isomeric forms.  Illegal, street-manufactured methamphetamine is the d-isomer, or a racemic mixture of the d and l, with the d- isomer being present at 20-100%.  The d- isomer also comes from the prescription drugs Desoxyn and Didrex.  L-methamphetamine occurs in the Vick’s inhaler, and as a metabolite of the Parkinson’s drug Eldepryl.  This test does not distinguish between d- and l- isomers.  If isomer separation is desired, contact the laboratory. 
 
INDICATIONS FOR USE:
Results are intended to provide the physicians/ clients of Saint Francis Health System with results obtained from the analysis of a urine specimen for the presence and/ or absence of prescribed or illicit drugs and their metabolites.  This test is for medical purposes only and is not intended to be used as a pre-employment screening assay or for legal forensic purposes.
 
ADDITIONAL RESOURCES: