FISH ANALYSIS, CHROMOSOME-SPECIFIC INTERPHASE
TURNAROUND TIME: 7 to 10 days
Fluorescence in situ hybridization
- Collect: 3-5 mL peripheral blood in sodium heparin (green) for children and adults; 1-2 mL peripheral blood in sodium heparin (green) for newborns
- Min. Collection: 1 mL for newborns; 2 mL for children and adults
- Transport: peripheral blood in sodium heparin (green) at 20-25°C
- Stability: Ambient: 24 hours; Refrigerated: 72 hours; Frozen: unacceptable
- Unacceptable Conditions: Frozen or clotted specimens; specimens in anticoagulants other than sodium heparin
A Cytogenetics Laboratory Test Requisition must accompany the specimen. Contact the Cytogenetics Laboratory at 918-502-1722 to obtain further information.
Test Summary: Test can detect trisomies of a specific chromosome or duplications of a chromosomal region.
Methods: A dual-color FISH analysis performed on interphase cells using probes for a specific chromosome locus and a control locus; analysis of 10 metaphase cells and 100 interphase cells
Indications for Use:
- Patients suspected of having a constitutional chromosome duplication or trisomy based on clinical features
- Confirmation of a chromosome abnormality suspected on routine or high resolution chromosome analysis