Maternal Cell Contamination (MCC) Studies

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MATERNAL CELL CONTAMINATION (MCC) STUDIES

TESTING METHODOLOGY:
Microsatellite-based polymerase chain reactions (PCR) at 15 well-characterized STR loci throughout the genome (D8S1179, D21S11, D7S820, CSF1PO, D3S1358, THO1, D13S317, D16S539, D2S1338, D19S433, vWA, TPOX, D18S51, D5S818, FGA).
 
SPECIMEN REQUIREMENTS:
  • Prenatal sample: Direct: 5ml direct unspun amniotic fluid or 15mg CVS tissue with a backup flask growing. Culture: confluent T25 flask. Maternal blood sample is required for maternal cell contamination studies.
  • Maternal sample: Prefer one 5ml whole blood EDTA (lavender top) tube from mother to compare with the prenatal sample. The minimum sample is 0.7 ml whole blood EDTA.
  • Transport: blood EDTA at Room Temp shipped regular next day air (No Saturday delivery; store specimen at 4°C and ship Monday).
  • Stability: Ambient: up to 3 days; Refrigerated: 2 weeks. Frozen: unacceptable
  • Unacceptable Conditions: Serum. Frozen or severely hemolyzed samples.
A Molecular Genetics Laboratory Test Requisition must accompany the specimen. Contact the Molecular Laboratory at 918-502-1721 to obtain further information.
Note: Counseling and informed consent are recommended for genetic testing. A consent form is available as a resource but not required.
 
INTERPRETATIVE DATA:
 
Purpose: To ensure the genetic results of a prenatal test reflect only the fetal DNA. If analysis reveals the appropriate inheritance of only one maternal allele, an accurate assessment of the fetal molecular genetic test result can be assured. Required for all prenatal molecular genetic testing.
 
Analytical Sensitivity: 99%
 
INDICATIONS FOR USE:
  • Molecular testing of prenatal specimens derived from CVS, culture or amniocentesis.